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Updated: Feb 25, 2026

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Local IL-25 contributes to Th2-biased inflammatory profiles in nasal polyps.

H-Y Hong^1,2, F-H Chen¹, Y-Q Sun¹

¹Allergy Center, Otorhinolaryngology Hospital, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

|August 4, 2017

Summary

Interleukin-25 (IL-25) is elevated in chronic rhinosinusitis with nasal polyps (CRSwNP), driving Th2 inflammation. Targeting IL-25 may offer a new therapeutic strategy for CRSwNP patients.

Keywords:

Th2 response chronic rhinosinusitis interleukin 25 nasal polyps

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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

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Published on: May 10, 2022

Area of Science:

Immunology
Otorhinolaryngology

Background:

Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated with Interleukin-25 (IL-25).
The role of IL-25 in CRSwNP pathogenesis and its link to Th2 inflammation require further investigation.

Purpose of the Study:

To investigate the association between IL-25 and Th2-biased inflammatory profiles in CRSwNP.
To evaluate IL-25 expression in nasal polyp tissues and its clinical relevance.

Main Methods:

Analyzed IL-25 expression in nasal polyp tissues from CRSwNP patients, chronic rhinosinusitis without nasal polyps (CRSsNP) patients, and controls using immunohistochemistry, immunofluorescence, flow cytometry, RT-qPCR, and ELISA.
Assessed inflammatory profiles and clinical characteristics of IL-25 high and low nasal polyp subtypes.
Examined the in vitro effects of IL-25 on Th2 cytokine production in cultured polyp cells.

Main Results:

Significantly increased IL-25 mRNA and protein levels were observed in nasal polyps compared to controls.
IL-25 high nasal polyps exhibited higher CT scan and endoscopic scores, alongside a pronounced Th2 response.
IL-25 exposure in vitro stimulated type 2 innate lymphoid cells and Th2 cells, enhancing Th2 cytokine production.

Conclusions:

Local IL-25 plays a critical role in promoting Th2-biased inflammation in nasal polyps.
IL-25 represents a potential therapeutic target for managing CRSwNP.