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Updated: Feb 25, 2026
10:19
Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
Published on: November 10, 2014
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Systemic Sarcoidosis with Thyroid Involvement
Hideyuki Okuma1,2, Koshi Hashimoto2,3, Xin Wang1
1Department of Endocrinology and Metabolism, Kashiwa City Kashiwa Hospital, Japan.
Internal Medicine (Tokyo, Japan)
|August 8, 2017
Summary
Sarcoidosis, a rare cause of thyroid disease, was diagnosed in a woman with hypercalcemia and lymph node hyperplasia. Thyroid core needle biopsy provided a definitive pathological diagnosis when other methods were declined.
Area of Science:
- Internal Medicine
- Pathology
- Radiology
Background:
- Sarcoidosis is an inflammatory disease characterized by granuloma formation.
- Thyroid involvement in sarcoidosis is uncommon, posing diagnostic challenges.
- Standard diagnostic procedures like bronchoscopy may not always be feasible.
Observation:
- A 66-year-old woman presented with malaise, hypercalcemia, and mediastinal/hilar lymphadenopathy.
- 67Gallium scintigraphy indicated widespread inflammation suggestive of sarcoidosis.
- The patient refused bronchoscopic examination for diagnosis.
Findings:
- Core needle biopsy (CNB) of the thyroid revealed epithelioid cell granulomas.
- Pathological examination confirmed sarcoidosis.
- This diagnosis was established despite the rarity of thyroid sarcoidosis.
Implications:
- Thyroid core needle biopsy serves as a viable alternative diagnostic tool for sarcoidosis.
- This case highlights the importance of considering sarcoidosis in patients with unexplained hypercalcemia and lymphadenopathy.
- Early and accurate diagnosis of sarcoidosis, even in unusual locations, is crucial for appropriate management.
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