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Related Concept Videos

Bone Cells and Tissue01:30

Bone Cells and Tissue

8.8K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
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Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

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Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
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The Bone Matrix01:18

The Bone Matrix

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
6.0K
Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Spongy Bone01:09

Spongy Bone

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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
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Related Experiment Video

Updated: Feb 24, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

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Bone-Forming Tumors.

Yaxia Zhang1, Andrew E Rosenberg2

  • 1Department of Pathology, Lerner College of Medicine, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue L25, Cleveland, OH 44195, USA.

Surgical Pathology Clinics
|August 12, 2017
PubMed
Summary
This summary is machine-generated.

Accurate diagnosis of bone-forming tumors requires correlating clinical, morphologic, and radiologic features. Histologic analysis of neoplastic bone can be subjective, necessitating advanced diagnostic methods for precise classification.

Keywords:
BoneFibrous dysplasiaNeoplasmOsteoblastomaOsteoid osteomaOsteosarcoma

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Area of Science:

  • Oncology
  • Pathology
  • Radiology

Background:

  • Bone-forming tumors are characterized by neoplastic cells differentiating into osteoblasts, producing neoplastic bone.
  • These tumors exhibit a wide range of morphologies and biological behaviors.
  • Accurate diagnosis is crucial for effective patient management and treatment planning.

Purpose of the Study:

  • To emphasize the importance of integrating clinical, morphologic, and radiologic findings for diagnosing bone-forming tumors.
  • To highlight the role of immunohistochemical and molecular analyses in challenging cases.
  • To discuss the current reliance on histologic analysis and its inherent subjectivity.

Main Methods:

  • Review of clinical, morphologic, and radiologic characteristics of bone-forming tumors.
  • Consideration of immunohistochemical and molecular diagnostic techniques.
  • Analysis of histologic features for tumor classification, including osteosarcoma subtypes.

Main Results:

  • The broad spectrum of bone-forming tumors necessitates a multimodal diagnostic approach.
  • Histologic identification of neoplastic bone is currently the primary method but can be subjective.
  • Osteosarcoma classification depends on morphology, origin, and histologic grade.

Conclusions:

  • A comprehensive diagnostic strategy combining clinical, imaging, and histologic data is essential for bone-forming tumors.
  • Advanced techniques like immunohistochemistry and molecular analysis aid in specific diagnoses.
  • Refining diagnostic criteria for neoplastic bone is important for improving accuracy and patient outcomes.