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Related Concept Videos

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Other Pulmonary Disorders01:17

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Association Between Hypercoagulability and Severe Obstructive Sleep Apnea.

Seung-No Hong1, Hee-Chul Yun1, Joon Hyuk Yoo1

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|August 18, 2017
PubMed
Summary
This summary is machine-generated.

Obstructive sleep apnea (OSA) is linked to cardiovascular disease. Moderate to severe OSA shows increased blood coagulability markers, suggesting a potential mechanism for these complications.

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Area of Science:

  • Cardiovascular Medicine
  • Sleep Medicine
  • Hematology

Background:

  • Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease.
  • The precise pathogenic mechanisms linking OSA and cardiovascular complications remain incompletely understood.
  • Alterations in blood coagulability are hypothesized to play a significant role in this association.

Purpose of the Study:

  • To investigate the relationship between the severity of obstructive sleep apnea (OSA) and markers of blood coagulability.
  • To determine if OSA severity correlates with specific coagulation test results.

Main Methods:

  • A retrospective cohort study was conducted involving 146 patients diagnosed with OSA.
  • Patients were stratified into four groups based on OSA severity: control, mild, moderate, and severe.
  • Coagulation parameters including platelet count, bleeding time, prothrombin time (PT) in seconds and INR, and activated partial thromboplastin time were analyzed.

Main Results:

  • Significant correlations were observed between the apnea-hypopnea index and both PT (seconds) and PT INR.
  • Patients with moderate and severe OSA exhibited significantly different PT seconds and PT INR compared to the control group.
  • No significant differences in PT seconds were found between the control and mild OSA groups.

Conclusions:

  • Moderate to severe obstructive sleep apnea is associated with elevated blood coagulability markers.
  • These findings suggest that increased coagulability in moderate to severe OSA may contribute to the heightened risk of cardiovascular complications.
  • Further research is warranted to elucidate the clinical implications of these coagulability changes.