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Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
Published on: October 4, 2019
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Polymer-based interconnection cables to integrate with flexible penetrating microelectrode arrays.
Keonghwan Oh1, Donghak Byun2, Sohee Kim3
1Department of Medical System Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.
Biomedical Microdevices
|August 27, 2017
Summary
New flexible interconnection cables were developed for neural interfacing electrodes, demonstrating durability and successful in-vivo neural signal recording in rabbits. This advancement enhances flexible penetrating microelectrode array systems.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Materials Science
Background:
- Neural interfacing electrodes require reliable interconnection methods.
- Existing methods like silicon ribbon cables and wire bonding may compromise electrode flexibility.
- Flexible Penetrating Microelectrode Arrays (FPMAs) offer advantages for neural recording and stimulation.
Purpose of the Study:
- To develop and evaluate novel interconnection cables for integration with FPMAs.
- To ensure the flexibility and durability of the interconnection cables for in-vivo applications.
- To validate the performance of the integrated system for neural signal acquisition.
Main Methods:
- Developed interconnection cables using polyimide and parylene C materials.
- Conducted long-term immersion tests in phosphate-buffered saline to assess durability.
- Measured impedance changes over time and utilized equivalent circuit models for analysis.
- Performed in-vivo implantation on rabbit sciatic nerves to record neural signals.
Main Results:
- Polyimide and parylene C cables maintained FPMA flexibility.
- Durability tests indicated suitability for in-vivo implantation.
- Electrochemical analysis provided insights into surface phenomena.
- Successful neural signal recording was achieved from the rabbit sciatic nerve.
Conclusions:
- The developed interconnection cables are suitable for integration with FPMAs.
- The flexible cable design preserves electrode functionality for neural interfacing.
- The integrated system demonstrates feasibility for neural recording and stimulation applications.
