Taurine Protects Mouse Liver Against Arsenic-Induced Apoptosis Through JNK Pathway
Shuangxing Li1, Lijun Yang2, Guangtao Dong1
1Department of Emergency Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
Abstract:
A great number of evidences demonstrated that the increased apoptosis is related to arsenic (As)-induced liver injury. The object of the present study was to explore the protection of taurine (Tau) against As-induced impairment in liver and the related mechanism. Adult mice were divided into control group, As exposure group and Tau protection group. The results of RT-PCR and WB showed that Tau treatment significantly reversed the disturbance of Bax and Bcl-2 expression. The release of cytochrome c and caspase-3 activation in liver both were prohibited by Tau in As-intoxicated mice. Furthermore, Tau markedly attenuated As-induced decrease of p-JNK level in mouse liver. These results indicated that Tau attenuated As-induced hepatic injury via JNK pathway.
