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Curvature of designed armadillo repeat proteins allows modular peptide binding

Simon Hansen1, Patrick Ernst1, Sebastian L B König1

  • 1Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.

Journal of Structural Biology
|September 3, 2017
PubMed
Summary

Consensus designed armadillo repeat proteins (dArmRPs) show optimal geometry for modular peptide binding. Crystal structures reveal insights into dArmRP curvature, confirming their potential as peptide-binding scaffolds.

Keywords:
Armadillo repeat proteinsPeptide bindingProtein crystallographyProtein engineeringSingle-molecule FRET

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