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Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

47
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
47
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

64
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
64
Drug Delivery: Overview01:16

Drug Delivery: Overview

992
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
992
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

33
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
33
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

43
Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
43
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

883
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
883

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Device-assisted transdermal drug delivery.

Hyunjae Lee1, Changyeong Song2, Seungmin Baik2

  • 1Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea.

Advanced Drug Delivery Reviews
|September 5, 2017
PubMed
Summary
This summary is machine-generated.

Advanced transdermal drug delivery overcomes skin barriers for enhanced, painless medication. Innovations include microneedles and biosensors for customized, real-time therapeutic delivery.

Keywords:
Controlled drug deliveryMicroneedlesSoft bioelectronicsTransdermal drug deliveryWearable biosensors

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Area of Science:

  • Biomedical Engineering
  • Pharmaceutics
  • Materials Science

Background:

  • Conventional oral and injectable drug delivery face limitations like side effects and inconvenience.
  • Transdermal drug delivery offers a painless, sustained release alternative but is hindered by skin's physiological barriers.
  • Existing transdermal systems primarily accommodate small, lipophilic molecules.

Purpose of the Study:

  • To review the evolution of transdermal drug delivery systems.
  • To highlight advancements beyond passive diffusion, including stimuli-responsive and microneedle-based technologies.
  • To discuss the integration of wearable biosensors for real-time physiological monitoring and customized drug release.

Main Methods:

  • Classification of advanced transdermal drug delivery strategies into generations.
  • Comprehensive review of recent technological advancements in the field.
  • Analysis of customized drug delivery systems utilizing real-time physiological data.

Main Results:

  • Transdermal drug delivery has progressed from passive diffusion to dynamic, externally controlled systems.
  • Microneedle technology effectively bypasses physical skin barriers.
  • Wearable biosensors enable controlled drug delivery based on physiological cues.

Conclusions:

  • Advanced transdermal systems offer improved drug delivery efficiency and patient convenience.
  • Future directions involve personalized medicine through real-time monitoring and responsive drug release.
  • These innovations promise enhanced therapeutic outcomes by overcoming traditional delivery challenges.