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Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
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Functional Hyper-Crosslinkers.

Ning Zhou1, Zeyuan Cao1, Bing Xu1

  • 1Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA, 02454, USA.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|September 8, 2017
PubMed
Summary
This summary is machine-generated.

Functional hyper-crosslinkers offer advanced polymer networks, enabling smart materials with stimuli-responsive and self-healing properties. These multifunctional crosslinkers introduce novel architectures and enhanced performance in soft materials.

Keywords:
crosslinkersfunctional groupspolymerssoft materialsstimuli-responsive

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Crosslinking enhances polymer mechanical and thermal properties, forming 3D structures.
  • Conventional crosslinkers act as simple bridges, unlike multifunctional biological counterparts.
  • Post-polymerization functional crosslinkers enable smart material design with stimuli-responsive properties.

Purpose of the Study:

  • Introduce hyper-crosslinkers (multifunctional, ≥3 crosslinking sites) for advanced polymer networks.
  • Explore applications in stimuli-responsive and self-healing soft materials.
  • Demonstrate how functional hyper-crosslinkers introduce new architectures and functionalities.

Main Methods:

  • Conceptual review of hyper-crosslinker designs.
  • Discussion of their role in stimuli-responsive polymer networks.
  • Analysis of anti-intuitive redox and thermal-pH responses in functionalized polymers.

Main Results:

  • Hyper-crosslinkers provide multiple crosslinking sites for complex network formation.
  • Polymers with functional hyper-crosslinkers exhibit unique stimuli-responsive behaviors.
  • These materials show potential for self-healing applications.

Conclusions:

  • Functional hyper-crosslinkers significantly enhance polymer physical and chemical performance.
  • They enable the creation of novel architectures and functionalities in soft materials.
  • This approach advances the development of smart, responsive, and self-healing polymeric systems.