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Updated: Feb 23, 2026

Fluorescence detection methods for microfluidic droplet platforms

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

Hybrid Integrated Silicon Microfluidic Platform for Fluorescence Based Biodetection.

Arvind Chandrasekaran¹, Ashwin Acharya², Jian Liang You²

¹CONCAVE Research Center, Optical Microsystems Laboratory, Dept. of Mechanical Engineering, CONCORDIA University, 1515 St. Catherine (o), Montreal, QC H3G2W1, Canada. achandra@alcor.concordia.ca.

Sensors (Basel, Switzerland)

|September 15, 2017

Summary

This summary is machine-generated.

Researchers developed an integrated silicon Lab-on-a-chip device for rapid, fluorescence-based biosensing. This novel device demonstrates feasibility for Point-of-Care diagnostics and high-throughput biomedical testing.

Keywords:

Anisotropic etching Biosensing Fluorescence Immobilization Lab-on-a-chip Micro-Opto-Electro-Mechanical Systems (MOEMS)Microfluidics Spectrometer-on-chip.

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Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

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Last Updated: Feb 23, 2026

Fluorescence detection methods for microfluidic droplet platforms

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

Area of Science:

Biomedical Engineering
Microfluidics
Biosensing

Background:

The need for integrated Lab-on-a-chip devices for rapid, in-situ biomedical diagnostics and Point-of-Care testing is growing.
Integration of microfluidics, microphotonics, immunoproteomics, and Micro ElectroMechanical Systems (MEMS) is crucial for advanced biosensing.

Purpose of the Study:

To develop a silicon-based microfluidic device for fluorescence-based immunoassay.
To demonstrate the feasibility of an integrated Lab-on-a-chip device for fluorescence biosensing by hybrid attachment with a Spectrometer-on-chip.

Main Methods:

Fabrication of a silicon-based microfluidic device.
Hybrid attachment of the microfluidic device with a Spectrometer-on-chip.
Biodetection using antigen sheep IgG and Alexafluor-647 tagged antibody particles.

Main Results:

Successful demonstration of an integrated Lab-on-a-chip device for fluorescence-based biosensing.
Experimental validation of silicon as a compatible material for microfluidic biosensing applications.

Conclusions:

Silicon is a suitable material for fabricating Lab-on-a-chip devices due to its cost-effectiveness, ease of microfabrication, and surface affinity for biomolecules.
The developed integrated device shows potential for high-throughput, Point-of-Care biomedical diagnostics.