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In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
Published on: January 21, 2018
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Laser-Induced Choroidal Neovascularizations: Clinical Study of 3 Cases
Wipada Laovirojjanakul1, Thuss Sanguansak1, Yosanan Yospaiboon1
1Department of Ophthalmology, KKU Eye Center, Khon Kaen University, Khon Kaen, Thailand.
Case Reports in Ophthalmology
|September 20, 2017
Summary
Laser photocoagulation can cause choroidal neovascularization (CNV). Intravitreal ranibizumab injections and photodynamic therapy (PDT) effectively treated laser-induced CNV in three patients, preventing complications.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Neovascularization
Background:
- Laser photocoagulation is a common ophthalmic procedure.
- Iatrogenic choroidal neovascularization (CNV) can occur as a complication.
- This study investigates laser-induced CNV in three patients.
Observation:
- Two patients with central serous chorioretinopathy developed iatrogenic CNV after focal laser treatment.
- One patient with diabetic macular edema developed CNV secondary to thermal laser treatment.
- Treatments included intravitreal ranibizumab injections and photodynamic therapy (PDT).
Findings:
- Intravitreal ranibizumab injections led to visual improvement and stable outcomes for over two years.
- PDT resulted in stable visual acuity but no improvement, potentially due to macular scarring and ischemia.
- No systemic or ocular complications were observed in any patient.
Implications:
- Avoiding heavy, small-spot laser burns and repeated applications is crucial for preventing laser-induced CNV.
- Close patient monitoring post-laser treatment is essential for early CNV detection.
- PDT and intravitreal ranibizumab injections demonstrate efficacy in managing laser-induced CNV.

