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Live or Let Die: New Developments in the Ongoing Debate Over Mannequin Death

Aaron W Calhoun1, David M Gaba

  • 1From the Division of Pediatric Critical Care (A.W.C.), Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY; Center for Immersive and Simulation-based Learning (D.M.G.), Stanford University School of Medicine; and Simulation Center; and VA Palo Alto HCS Anesthesia Service (D.M.G.), Palo Alto, CA.

Simulation in Healthcare : Journal of the Society for Simulation in Healthcare
|September 20, 2017
PubMed
Abstract

No abstract available in PubMed .

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Clearance Models: Physiological Models01:09

Clearance Models: Physiological Models

Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
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