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Neuromyelitis Optica in a Nepalese Man
Yogesh Subedi1, Utsav Joshi1, Sanjeeb Sudarshan Bhandari1
1Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
Case Reports in Neurological Medicine
|September 22, 2017
Summary
Neuromyelitis optica (NMO) is an autoimmune CNS disorder. Early immunosuppressive treatment, even without diagnostic tests, improved a patient with NMO-IgG positive symptoms.
Area of Science:
- Neurology
- Immunology
- Neuroinflammation
Background:
- Neuromyelitis optica (NMO) is a severe autoimmune inflammatory disease targeting the central nervous system, primarily the optic nerves and spinal cord.
- It is characterized by significant disability and is of autoimmune etiology.
- This case report focuses on a patient presenting with symptoms indicative of NMO.
Observation:
- A 46-year-old man presented with a two-month history of progressive tingling and weakness in his right upper and lower limbs.
- Clinical examination revealed diminished muscle strength in the affected limbs.
- Cervical spine MRI showed abnormalities consistent with myelitis or demyelination in the spinal cord.
Findings:
- The patient tested positive for neuromyelitis optica immunoglobulin G (NMO-IgG).
- Treatment with intravenous methylprednisolone was initiated promptly.
- The patient showed clinical improvement following treatment.
Implications:
- Early initiation of aggressive immunosuppressive therapy is crucial for managing NMO, even in resource-limited settings.
- Prompt treatment can lead to significant clinical improvement and mitigate disability.
- This case underscores the importance of timely intervention in suspected NMO cases.
