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Topical Nano and Microemulsions for Skin Delivery
Christofori M R R Nastiti1,2, Thellie Ponto3, Eman Abd4
1School of Pharmacy, Curtin Health Innovation Research Institute, Curtin University, G.P.O. Box U1987, Perth, WA 6845, Australia. c.nastiti@postgrad.curtin.edu.au.
Pharmaceutics
|September 22, 2017
Summary
Microemulsions (ME) and nanoemulsions (NE) are effective nanosystems for targeted skin drug delivery. Formulation adjustments optimize bioavailability and reduce skin irritation for topical and transdermal applications.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Dermatology
Background:
- Nanosystems like microemulsions (ME) and nanoemulsions (NE) are promising for drug delivery.
- These stable colloidal systems are composed of oil, water, surfactants, and cosurfactants.
- They are of particular interest for topical and transdermal skin applications.
Purpose of the Study:
- To review nanosystems for skin delivery, focusing on ME and NE.
- To discuss the composition and characterization of ME and NE for topical and transdermal delivery.
- To examine skin delivery mechanisms across the stratum corneum and via hair follicles.
Main Methods:
- Literature review of nanosystems for skin delivery.
- Analysis of ME and NE composition and characterization.
- Review of skin penetration enhancement mechanisms.
Main Results:
- ME and NE offer significant potential for targeted skin drug delivery.
- Formulation components can be manipulated to optimize bioavailability and minimize skin irritancy.
- Penetration enhancers can fluidize stratum corneum lipids, increasing permeation.
Conclusions:
- Nanosystems, particularly ME and NE, are versatile for topical and transdermal drug delivery.
- Careful formulation design is crucial for enhancing drug bioavailability and ensuring skin compatibility.
- Understanding delivery mechanisms through the stratum corneum and hair follicles is key to optimizing nanosystem performance.
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