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Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
Published on: January 31, 2025
Exosomes-Based Biomarkers for the Prognosis of Cardiovascular Diseases
Yihua Bei1, Pujiao Yu2, Dragos Cretoiu3,4
1Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.
Insights
Exosomes show promise as sensitive biomarkers for predicting cardiovascular disease (CVD) outcomes. Further research is needed to confirm their clinical benefits over existing prognostic tools.
Area of Science:
- Biomedical Science
- Molecular Biology
- Cardiology
Background:
- Cardiovascular diseases (CVDs) present a significant global health challenge with high mortality and morbidity.
- Accurate prognostic biomarkers are crucial for personalized treatment strategies in CVD management.
- Exosomes, found in body fluids, offer potential as indicators of disease progression.
Purpose of the Study:
- To review and summarize exosome-based biomarkers for the prognosis of various cardiovascular diseases.
- To highlight the potential of exosomes in assessing disease stage and progression.
Main Methods:
- Literature review and synthesis of existing studies on exosome biomarkers in cardiovascular diseases.
- Focused on coronary artery disease, heart failure, stroke, hypertension, cardiac arrhythmia, cardiomyopathy, valvular heart diseases, and pulmonary arterial hypertension.
Main Results:
- Exosomes are present in most body fluids and can reflect disease status.
- This review consolidates current knowledge on exosome-based prognostic markers across a spectrum of CVDs.
Conclusions:
- Exosome-based biomarkers hold potential for improving cardiovascular disease prognosis.
- Further large-scale, multicenter studies are essential to validate their efficacy compared to current biomarkers.
Abstract:
Cardiovascular diseases (CVDs) have a high prevalence and annually increasing incidence with high mortality and morbidity. Identification of biomarkers with high sensitivity and specificity for assessing the prognosis of CVDs is necessary for optimizing personalized treatment and reducing mortality. Exosomes have been proved to be accessible in nearly all body fluids and they can reflect disease stage or progression. Here we summarized exosomes-based biomarkers for the prognosis of coronary artery diseases, heart failure, stroke, hypertension, cardiac arrhythmia, cardiomyopathy, valvular heart diseases and pulmonary arterial hypertension. If exosome-based biomarkers can achieve additionally benefits as compared to the present prognostic biomarkers remains to be determined and multicenter studies with large cohorts of patients are highly needed.
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