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Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles

Brian S Safina1, Richard L Elliott2, Andrew K Forrest2

  • 1Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.

ACS Medicinal Chemistry Letters
|September 27, 2017
PubMed

Keywords:
PI3K delta inhibitorPI3K isoform selectivityligand-based design

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