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Updated: Feb 22, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
Effect of Electroconvulsive Therapy on Cognitive Functions of Rats with Depression-Like Disorders Induced by
V M Ushakova1, E A Zubkov2, A Y Morozova2
1Department of Higher Nervous Function, M. V. Lomonosov Moscow State University, Moscow, Russia. scobelevavm@gmail.com.
Abstract:
We studied the effect of electroconvulsive therapy on cognitive functions in rats with depression-like disorder caused by exposure to ultrasound of varying frequency (20-45 kHz). Object recognition and Morris water-maze tests revealed no negative effects of the therapy on memory. Moreover, positive effect of therapy was demonstrated that manifested in amelioration of memory disturbances in depression-like disorders in these behavioral tests. The results of this study do not support the idea about side effects of electroconvulsive therapy, in particular, development of transient amnesia, and are a prerequisite for a more thorough study of internal mechanisms of the effect of the therapy on cognitive sphere.

