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Changes in the Proteome of HaCaT Keratinocytes Induced by Cytotoxic Substance Triton X-100
A L Rusanov1, K V Nakhod2, V I Nakhod2
1Perspective Company, Novosibirsk, Russia. alexander.l.rusanov@gmail.com.
Bulletin of Experimental Biology and Medicine
|September 28, 2017
Abstract:
Changes in the proteome of keratinocytes of immortalized HaCaT line exposed to cytotoxic substance Triton X-100 in concentrations of 12.5 and 25 μg/ml were studied by liquid chromatography combined with mass spectrometry. The appearance of proteins involved in the regulation of mitosis, RNA stability, and catabolic processes were detected; the number of apoptosis-associated proteins increased, while the number of proteins involved in differentiation and energy metabolism of keratinocytes decreased.
