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Updated: Feb 21, 2026

Assays for the Degradation of Misfolded Proteins in Cells
Published on: August 28, 2016
Molecular Chaperones in Neurodegenerative Diseases: A Short Review
Catherine Bobori1, Georgia Theocharopoulou2, Panayiotis Vlamos3
1Bioinformatics and Human Electrophysiology Laboratory (BiHELab), Department of Informatics, Ionian University, 7 Tsirigoti Square, Corfu, Greece.
Abstract:
Stress and misfolded proteins result to dysfunction in the cell, often leading to neurodegenerative diseases and aging. Misfolded proteins form toxic aggregates that threaten cell's stability and normal functions. In order to restore its homeostasis, the cell activates the UPR system. Leading role in the restoration play the molecular chaperones which target the misfolded proteins with the purpose of either helping them to unfold and refold to their natural state or lead them degradation. This paper aims to present some of the most known molecular chaperones and their relation with diseases associated to protein misfolding and neurodegeneration, as well as the role of chaperones in proteostasis.
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