[Cinnamon rolls triggered anaphylactic reaction. The genesis could be wheat-dependent exercise-induced anaphylaxis]

Cinnamon rolls triggered anaphylactic reaction. The genesis could be wheat-dependent exercise-induced anaphylaxis Two case reports from our Department of Allergology illustrate the wheat-dependent exercise-induced anaphylaxis (WDEIA), which is a relatively rare, yet potentially fatal form of food allergy. Wheat (Triticum aestivum) is the most commonly grown crop world-wide, and some individuals cannot tolerate it due to wheat hypersensitivity. The most dangerous reaction is the anaphylaxis due to harmful immune responses to various parts of the wheat proteins. ω-5-gliadin is the major causative allergen in wheat hypersensitivity. WDEIA is a poorly recognized disorder. Therefore, any patient presenting anaphylactic reaction at the emergency department, typically after ingestion of wheat products followed by physical exercise within one to four hours, should be referred to an allergy clinic for the allergological evaluation. Further research should be carried out to better understand the mechanisms behind, and to increase the awareness on WDEIA.