Related Experiment Videos
[The identity of normal and cancer stem cells]
1CNRS U8590 - Institut d'histoire et de philosophie des sciences et des techniques (IHPST), université Paris I Panthéon-Sorbonne, 13, rue du Four, 75006 Paris, France - Inserm U1170, Gustave Roussy, 114, rue Edouard Vaillant, 94800 Villejuif, France.
Medecine Sciences : M/S
|October 11, 2017
Abstract:
What is a stem cell? Is stemness an intrinsic or extrinsic property? What role does the microenvironment play in the stemness identity? We distinguish four identities for normal and cancerous stem cells and explore their consequences for therapeutic strategy choice in the oncology setting. Acquisition of genetic and epigenetic alterations during cell transformation and disease progression questions the stability of the stemness property's identity in cancers.