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Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
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Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me

Rodrigo San-Cristobal1, Santiago Navas-Carretero2,3, Katherine M Livingstone4

  • 1Department of Nutrition, and Food Science Physiology, Centre for Nutrition Research, University of Navarra, 31008 Pamplona, Spain. rsan.1@alumni.unav.es.

Nutrients
|October 12, 2017
PubMed
Summary
This summary is machine-generated.

Mediterranean Diet (MedDiet) adherence benefits metabolic health, but genetic background influences outcomes. A high MedDiet Score improved BMI, waist circumference, and glucose, while genetic risk score affected cholesterol and carotenoid levels.

Keywords:
Food4Me studyMediterranean dietgenetic riskobesity

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Area of Science:

  • Nutritional Science
  • Genetics
  • Metabolic Health

Background:

  • Mediterranean Diet (MedDiet) offers health benefits.
  • Nutrigenetics explains individual dietary response variations.
  • Understanding gene-diet interactions is crucial for personalized nutrition.

Purpose of the Study:

  • To investigate associations between MedDiet adherence and genetic background.
  • To explore potential interactions influencing metabolic health.
  • To analyze data from the Food4Me web-based nutritional intervention.

Main Methods:

  • Collected dietary, anthropometrical, and biochemical data over 6 months.
  • Analyzed genetic variants related to metabolic risk, creating a Genetic Risk Score (GRS).
  • Estimated Mediterranean Diet Score (MDS) from food intake data.

Main Results:

  • High baseline MDS correlated with reduced BMI, waist circumference, and glucose.
  • Low GRS showed a greater decrease in total cholesterol.
  • Significant interaction found post-intervention: high MedDiet adherence reduced carotenoids in high GRS individuals.

Conclusions:

  • Higher MedDiet adherence positively impacts metabolic outcomes.
  • Genetic background modulates the effects of MedDiet on specific markers.
  • Gene-diet interactions are key in personalized nutrition strategies.