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Updated: Feb 20, 2026

Micro-scale Engineering for Cell Biology
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Published on: October 1, 2007

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Introduction.

Erica A Fortson1, Becky Li2, Mahima Bhayana2

  • 1Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC, USA. efortson@wakehealth.edu.

Advances in Experimental Medicine and Biology
|October 25, 2017
PubMed
Summary
This summary is machine-generated.

Atopic dermatitis (AD) is a widespread skin condition causing itching and redness. Current treatments manage symptoms, but exploring new trends and patient care strategies is crucial for better outcomes.

Keywords:
Asthma-eczemaAtopic dermatitisAtopic eczemaBesnier’s prurigoEczema flexurarumEndogenous eczemaHay fever-eczemaIntrinsic allergic dermatitisNeurodermitis constitutionalis

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Micro-scale Engineering for Cell Biology
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Area of Science:

  • Dermatology
  • Immunology
  • Epidemiology

Background:

  • Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin condition characterized by pruritus and erythema.
  • The term 'atopic dermatitis' was coined in 1933, linking skin conditions with respiratory atopy like asthma and allergic rhinitis.
  • AD is a global health issue, with lifetime prevalence exceeding 20% in affluent nations, influenced by climate, urbanization, lifestyle, and socioeconomic factors.

Purpose of the Study:

  • To explore the complexities of atopic dermatitis etiology and management.
  • To provide healthcare providers with practical strategies to enhance patient care and satisfaction.
  • To highlight emerging trends and future treatment approaches for AD.

Main Methods:

  • Systematic review of 69 cross-sectional and cohort studies to assess global AD prevalence.
  • Analysis of factors influencing AD prevalence, including environmental, genetic, and immune mechanisms.
  • Review of current management strategies, encompassing non-pharmacologic modalities and prescription medications.

Main Results:

  • Atopic dermatitis is a worldwide phenomenon with significant prevalence in developed countries.
  • Disease progression is driven by a complex interplay of extrinsic environmental factors, intrinsic immune mechanisms, and genetic predispositions.
  • Current management focuses on symptomatic control, with significant patient-reported barriers including time, cost, and side effects.

Conclusions:

  • Understanding the multifaceted etiology of AD is essential for improving patient care.
  • Addressing patient barriers to treatment is critical for effective management.
  • Future research and clinical practice should focus on innovative treatment modalities for atopic dermatitis.