Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replication in Eukaryotes02:31

Replication in Eukaryotes

206.1K
Overview
206.1K
Replication in Eukaryotes01:29

Replication in Eukaryotes

17.9K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
17.9K
Replication in Prokaryotes01:32

Replication in Prokaryotes

28.3K
DNA replication has three main steps: initiation, elongation, and termination. Replication in prokaryotes begins when initiator proteins bind to the single origin of replication (ori) on the cell's circular chromosome. Replication then proceeds around the entire circle of the chromosome in each direction from the two replication forks, resulting in two DNA molecules.
Many Proteins Work Together to Replicate the Chromosome
Replication is coordinated and carried out by a host of specialized...
28.3K
Replication in Prokaryotes02:35

Replication in Prokaryotes

99.7K
Overview
99.7K
The Replisome03:01

The Replisome

38.6K
DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
38.6K
The Replisome03:01

The Replisome

10.5K
10.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating the reproducibility of the social and behavioural sciences.

Nature·2026
Same author

Investigating the replicability of the social and behavioural sciences.

Nature·2026
Same author

A nondogmatic approach to boldness: Reply to Athar et al. (2026).

Psychological assessment·2026
Same author

How Novices Interpret Generalizations and How Experts Use Them.

Cognitive science·2026
Same author

Evaluating Associations Between Friendship Characteristics and Mental, Physical, and Cognitive Health.

Research on aging·2025
Same author

Perceptions of science, science communication, and climate change attitudes in 68 countries - the TISP dataset.

Scientific data·2025
Same journal

Are language models models?

The Behavioral and brain sciences·2026
Same journal

Large language models illuminate the mechanistic underpinnings of the creative aspect of language use (CALU), long regarded as a mystery.

The Behavioral and brain sciences·2026
Same journal

LLMs as a platform for studying constraint interaction: Motivation and challenges.

The Behavioral and brain sciences·2026
Same journal

Beyond the data gap: Children create languages, violate their input statistics, and exhibit critical periods.

The Behavioral and brain sciences·2026
Same journal

Not-so-strange love: Language models and generative linguistic theories are more compatible than they appear.

The Behavioral and brain sciences·2026
Same journal

Rich data drive generalization: Lessons from machine learning for linguistics and cognitive science.

The Behavioral and brain sciences·2026
See all related articles

Related Experiment Video

Updated: Feb 20, 2026

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

13.0K

Making replication mainstream.

Rolf A Zwaan1, Alexander Etz2, Richard E Lucas3

  • 1Department of Psychology, Education, and Child Sciences, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands. zwaan@essb.eur.nlhttps://www.eur.nl/essb/people/rolf-zwaan.

The Behavioral and Brain Sciences
|October 26, 2017
PubMed
Summary
This summary is machine-generated.

Replication is key to scientific evidence, but many high-profile studies fail to replicate. This work reviews replication methods and concerns, concluding direct replication can be routine in psychological science.

Keywords:
psychological researchreplicationreproducibilityresearch programs

More Related Videos

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
06:40

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

Published on: March 22, 2018

6.3K
Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience
10:17

Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience

Published on: November 15, 2024

1.8K

Related Experiment Videos

Last Updated: Feb 20, 2026

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
11:22

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

13.0K
G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
06:40

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

Published on: March 22, 2018

6.3K
Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience
10:17

Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience

Published on: November 15, 2024

1.8K

Area of Science:

  • Philosophy of Science
  • Scientific Methodology
  • Psychological Science

Background:

  • Replication is crucial for establishing scientific evidence.
  • Recent replication attempts in psychology and other fields have faced challenges and controversy.
  • Discourse on replication's value is fragmented across various platforms.

Purpose of the Study:

  • To review different types of replication studies.
  • To address common concerns regarding direct replication.
  • To propose statistical methods for evaluating replications.

Main Methods:

  • Literature review of replication studies.
  • Analysis of common criticisms of direct replication.
  • Exploration of statistical approaches for assessing replication success.

Main Results:

  • Identified various types of replication studies.
  • Detailed responses provided to prevalent concerns about direct replication.
  • Considered statistical methods for evaluating replication outcomes.

Conclusions:

  • Direct replication is a valuable component of scientific progress.
  • No theoretical or statistical barriers prevent direct replication from becoming standard practice.
  • Integrating direct replication can enhance the reliability of scientific findings, particularly in psychology.