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Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels
Jinyu Wang1, Weibo Zhao2, Haixiao Chen3
1College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225200, Jiangsu, People's Republic of China.
Abstract:
Self-assembly nanogels (NGs) were formed by bioconjugating methotrexate (MTX) with chondroitin sulfate (CS). MTX-CS NGs can greatly enhance the solubility and improve the delivery efficacy of MTX due to the CD44 binding property of CS. Vivo experiments revealed that MTX-CS NGs showed less toxicity than MTX. MTX-CS NGs can improve the anti-tumor effect while reducing the side effects of MTX. Due to their CD44 binding property, chondroitin sulfate-drug conjugates could be a promising and efficient platform for improving the solubility of sparingly soluble drug molecules as well as targeted delivery to cancer cells and tumor tissues.
