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Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry
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Oncologic Metabolic Emergencies.

Jonathan Wagner1, Sanjay Arora1

  • 1Department of Emergency Medicine, Keck School of Medicine of the University of Southern California, 1200 North State Street, Room 1011, Los Angeles, CA 90033, USA.

Hematology/Oncology Clinics of North America
|October 29, 2017
PubMed
Summary
This summary is machine-generated.

Emergency providers must recognize and manage oncologic metabolic emergencies like tumor lysis syndrome and hypercalcemia of malignancy. Prompt diagnosis and treatment in the emergency department save lives and improve quality of life for cancer patients.

Keywords:
CancerEmergency medicineHypercalcemia of malignancyMetabolic emergencyTreatmentTumor lysis syndrome

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Area of Science:

  • Oncology
  • Emergency Medicine
  • Metabolic Disorders

Background:

  • Cancer and its treatments can precipitate life-threatening metabolic emergencies.
  • These emergencies require prompt recognition and management by emergency providers.
  • Oncologic metabolic emergencies can occur in advanced disease, during treatment, or as an initial presentation.

Purpose of the Study:

  • To review the two most critical oncologic metabolic emergencies: tumor lysis syndrome and hypercalcemia of malignancy.
  • To provide emergency providers with essential information for identifying and managing these conditions.
  • To discuss the associated cancers, pathophysiology, and recommended treatments.

Main Methods:

  • Literature review focusing on tumor lysis syndrome and hypercalcemia of malignancy in cancer patients.
  • Analysis of pathogenesis, clinical presentation, and diagnostic criteria.
  • Synthesis of current management guidelines and treatment strategies for emergency settings.

Main Results:

  • Tumor lysis syndrome and hypercalcemia of malignancy are critical oncologic emergencies.
  • Understanding the underlying pathophysiology is key to effective management.
  • Early intervention in the emergency department significantly impacts patient outcomes.

Conclusions:

  • Emergency providers need expertise in managing metabolic emergencies in cancer patients.
  • Prompt diagnosis and treatment of tumor lysis syndrome and hypercalcemia of malignancy are crucial.
  • This review provides a framework for managing these emergent oncologic conditions.