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Chemodenervation of the Larynx
Rachel Kaye1, Andrew Blitzer2,3,4
1Department of Otorhinolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, 90 Bergen Street, Suite 8100, Newark, NJ 07103, USA. rachelkayemd@gmail.com.
Toxins
|November 4, 2017
Summary
Botulinum neurotoxin (BoNT) offers a safe and effective treatment for laryngeal disorders like spasmodic dysphonia. This chemodenervation technique can reduce medication needs and prevent surgery.
Area of Science:
- Neurolaryngology
- Medical Neuroscience
- Pharmacology
Background:
- Botulinum neurotoxin (BoNT) has ancient origins but medical applications emerged in the late 1970s-1980s.
- Spasmodic dysphonia reclassification as focal dystonia facilitated chemodenervation.
- BoNT is explored for various neurolaryngology conditions due to its safety and efficacy.
Purpose of the Study:
- To review the history, development, and application of BoNT in laryngeal disorders.
- To focus on BoNT's role in treating spasmodic dysphonia.
- To discuss mechanisms, uses, and administration techniques of BoNT for laryngeal conditions.
Main Methods:
- Review of historical data and medical literature.
- Analysis of BoNT's therapeutic applications in neurolaryngology.
- Examination of chemodenervation techniques for laryngeal disorders.
Main Results:
- BoNT is a safe and effective treatment for spasmodic dysphonia, vocal tremor, and muscle tension dysphonia.
- Chemodenervation with BoNT can serve as an adjunct therapy.
- BoNT may reduce reliance on oral medications or surgical interventions.
Conclusions:
- Botulinum neurotoxin is a valuable therapeutic agent for specific laryngeal disorders.
- Its application in neurolaryngology, particularly for spasmodic dysphonia, is a refined technique.
- BoNT offers a viable alternative to pharmacotherapy and surgery for certain patients.
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