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Isotretinoin-induced Angle Closure and Myopic Shift
Young-Myoung Park1, Tae-Eun Lee
1Department of Ophthalmology, Chonbuk National University Medical School, Jeonju, Korea.
Journal of Glaucoma
|November 4, 2017
Summary
Isotretinoin acne therapy can cause rare, temporary vision problems. This case report details managing transient myopia and angle closure with increased intraocular pressure (IOP) during treatment.
Area of Science:
- Ophthalmology
- Dermatology
Background:
- Isotretinoin is a common treatment for severe acne.
- Ocular side effects of isotretinoin are uncommon but can be serious.
Observation:
- A 28-year-old woman developed sudden bilateral myopia, angle closure, and elevated intraocular pressure (IOP).
- These symptoms emerged one week after initiating oral isotretinoin for acne.
- Ultrasound biomicroscopy revealed supraciliary effusions.
Findings:
- Discontinuation of isotretinoin and treatment with topical steroids, cycloplegics, and IOP-lowering drops resolved the symptoms.
- Refraction, IOP, and ocular ultrasound findings normalized within two weeks.
Implications:
- This case highlights a potential, albeit rare, adverse ocular reaction to isotretinoin.
- Ophthalmologists and dermatologists should be aware of the possibility of transient myopia and angle closure during isotretinoin therapy.
- Prompt recognition and management are crucial for visual recovery.
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