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Updated: Feb 19, 2026

Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation
Published on: October 1, 2012
Immunology of Gut-Bone Signaling
Fraser L Collins1, Jonathan D Schepper1, Naiomy Deliz Rios-Arce1,2
1Department of Physiology, Michigan State University, East Lansing, MI, USA.
Abstract:
In recent years a link between the gastrointestinal tract and bone health has started to gain significant attention. Dysbiosis of the intestinal microbiota has been linked to the pathology of a number of diseases which are associated with bone loss. In addition modulation of the intestinal microbiota with probiotic bacteria has revealed to have both beneficial local and systemic effects. In the present chapter, we discuss the intestinal and bone immune systems, explore how intestinal disease affects the immune system, and examine how these pathologic changes could adversely impact bone health.
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