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Stomach and Bone.

Alice M Kitay1, John P Geibel2

  • 1Department of Surgery, Yale School of Medicine, New Haven, CT, USA.

Advances in Experimental Medicine and Biology
|November 5, 2017
PubMed
Summary
This summary is machine-generated.

The gut and bone metabolism are closely linked, with gastric acid secretion playing a key role. Imbalances in hormones like calcitriol and calcium regulation via CaSR impact skeletal health.

Keywords:
CaSRCalciumGastric acidGastrointestinal tractIonic homeostasisOsteoporosisPPIPTHSkeletonVitamin D

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Area of Science:

  • Gastroenterology and Bone Metabolism
  • Endocrinology
  • Calcium Homeostasis

Background:

  • The relationship between gastrointestinal organs and bone metabolism is increasingly understood.
  • Gastric acid secretion is tightly regulated with bone metabolism, impacting skeletal health.
  • Endocrine modulators like calcitriol (1,25(OH)2 vitamin D), PTH, and calcitonin are crucial for skeletal integrity.

Purpose of the Study:

  • To elucidate the intricate connection between gastric acid secretion and bone metabolism.
  • To highlight the role of calcium and the calcium-sensing receptor (CaSR) in the gut-bone signaling axis.
  • To discuss diseases and therapeutic implications arising from imbalances in this axis.

Main Methods:

  • Review of current literature on gut-bone signaling.
  • Analysis of the roles of key endocrine modulators (calcitriol, PTH, calcitonin).
  • Examination of calcium homeostasis and the calcium-sensing receptor (CaSR) in relevant tissues.

Main Results:

  • The gut-bone signaling axis is a critical determinant of skeletal health.
  • Dysregulation of gastric acid secretion and calcium homeostasis significantly impacts bone metabolism.
  • The CaSR plays a vital role in maintaining calcium balance across multiple organs.

Conclusions:

  • Understanding the gut-bone axis is essential for managing metabolic bone diseases.
  • Therapeutic strategies targeting gastric acid and calcium regulation may offer new avenues for skeletal health.
  • Further research into the CaSR's function could yield novel treatments for bone disorders.