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Updated: Feb 19, 2026

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
Published on: September 10, 2018
PROPHYLACTIC USE OF 15(S)15 METHYL PGF2α FOR CONTROL OF POSTPARTUM BLEEDING
Abstract:
The efficacy of 15(S)15 methyl PGF2α (Prostin 15M, Upjohn) was tested in controlling the bleeding during third stage of labour in women delivered at term. Prostin 15M was given in a dose of 125 µg by intramuscular route at the delivery of the anterior shoulder of the fetus. Prostin 15M significantly reduced the duration of third stage and blood loss to about a third of those who did not receive any oxytocic. The blood loss during 2 hours following delivery was also markedly reduced with Prostin 15M treatment.
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