Related Experiment Video
Updated: Feb 19, 2026
09:04
Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
Published on: September 10, 2018
10.2K
STUDIES ON 15(S)15 METHYL PGF2α BY INTRAMUSCULAR ROUTE FOR SECOND TRIMESTER ABORTION (THREE HOURLY SCHEDULE)
Acta Obstetricia Et Gynecologica Scandinavica
|November 10, 2017
Summary
Intramuscular Prostin 15M effectively induced second-trimester abortions in most women. This prostaglandin analogue demonstrated a high success rate with a low incidence of incomplete abortion, making it a viable option for pregnancy termination.
Area of Science:
- Obstetrics and Gynecology
- Reproductive Medicine
- Pharmacology
Background:
- Second-trimester abortion induction requires effective and safe methods.
- Prostaglandins are commonly used for labor induction and abortion.
- 15(S)-5 methyl PGF2α (Prostin 15M) is a prostaglandin analogue with potential for abortion induction.
Purpose of the Study:
- To evaluate the efficacy and safety of intramuscular 15(S)-5 methyl PGF2α for second-trimester abortion induction.
- To determine the induction-abortion interval and incidence of side effects.
Main Methods:
- A multicenter study involving 62 patients undergoing second-trimester abortion.
- Patients received intramuscular Prostin 15M (250 µg) every three hours, with premedication for gastrointestinal side effects.
- Treatment failure was defined as no progress after 10 injections.
Main Results:
- The treatment was successful in 23 out of 24 primigravidae and 34 out of 38 multigravidae.
- Mean induction-abortion intervals were 23.5 hours for primigravidae and 18.0 hours for multigravidae.
- The overall incidence of incomplete abortion was 10.5%, with mean vomiting at 2.9 and diarrhea at 5.0 episodes.
Conclusions:
- Intramuscular 15(S)-5 methyl PGF2α is an effective agent for inducing second-trimester abortion.
- The drug shows a favorable safety profile with a low rate of incomplete abortion.
- Prostin 15M offers a viable therapeutic option for second-trimester pregnancy termination.
