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Updated: Feb 18, 2026

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

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Published on: April 17, 2020

Brain Death.

Mack Drake¹, Andrew Bernard¹, Eugene Hessel²

¹Section on Trauma and Acute Care Surgery, Division of General Surgery, Department of Surgery, University of Kentucky College of Medicine, C224, 800 Rose Street, Lexington, KY 40536-0298, USA.

The Surgical Clinics of North America

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Summary

Brain death determination requires careful evaluation to prevent errors. Accurate diagnosis and support are crucial for end-of-life care and organ donation.

Keywords:

Ancillary testing Brain death Brain injury Clinical examination Confirmatory testing Critical care Organ donor

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Published on: June 22, 2013

Area of Science:

Neurology
Critical Care Medicine

Background:

Brain death, defined by cessation of entire brain function, has explicit diagnostic criteria.
Nuances in evaluation and potential confounders remain areas of controversy.
Accurate diagnosis is critical due to the catastrophic consequences of misdiagnosis.

Purpose of the Study:

To emphasize the importance of standardized processes in brain death determination.
To highlight the role of clinicians and checklists in preventing diagnostic errors.
To underscore the significance of timely and accurate brain death diagnosis for patient care and organ donation.

Main Methods:

Review of diagnostic criteria for brain death.
Discussion of potential confounders and nuances in clinical evaluation.
Emphasis on the use of standardized processes and checklists by hospital and ICU teams.

Main Results:

Explicit diagnostic criteria for brain death exist.
Potential for diagnostic errors due to evaluation nuances and confounders.
Standardized processes, including checklists, can prevent errors.

Conclusions:

Careful consideration of clinicians and standardized processes, including checklists, is essential for accurate brain death testing.
Timely and accurate brain death determination, coupled with aggressive physiologic support, is fundamental for optimal end-of-life care and successful organ donation.