Related Experiment Video
Updated: Feb 18, 2026

12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
10.9K
Granulomatous pigmented purpuric dermatosis.
Adam Allan1, David A Altman1, Wei Su1
1Department of Dermatology, Saint Joseph Mercy Health System, Ann Arbor, Michigan, USA.
Cutis
|November 15, 2017
Summary
Granulomatous pigmented purpuric dermatosis (GPPD) is a rare skin condition. This case report details a GPPD presentation in an elderly Caucasian male, challenging previous associations with hyperlipidemia and East Asian prevalence.
Area of Science:
- Dermatology
- Histopathology
Background:
- Granulomatous pigmented purpuric dermatosis (GPPD) is a rare histological variant of pigmented purpuric dermatosis (PPD).
- GPPD is characterized by classic PPD changes with superimposed granulomas.
- Historically, GPPD has been associated with hyperlipidemia and prevalence in the Far East.
Observation:
- A case of GPPD is presented in an elderly Caucasian male.
- The patient exhibited an eruption predominantly affecting the lower legs.
Findings:
- A review of 26 documented GPPD cases suggests that associations with hyperlipidemia and East Asian ethnicity may be less clear.
- This case adds to the understanding of GPPD presentation in diverse populations.
Implications:
- The findings suggest a broader spectrum of clinical presentation for GPPD.
- Further research is needed to clarify the etiology and epidemiology of GPPD.
- This case highlights the importance of considering GPPD in elderly individuals with purpuric eruptions, regardless of traditional risk factors.
Related Concept Videos
Pigmentation
4.6K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.6K
Skin Diseases and Disorders
5.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.8K
Changes in Skin Color: Clinical Perspectives
3.9K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.9K
Endocarditis II: Clinical Features of Infective Endocarditis
584
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
584

