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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X

Carika Weldon1, Justine G Dacanay1, Vijay Gokhale2

  • 1Leicester Institute of Structural & Chemical Biology and Department of Molecular & Cell Biology, University of Leicester, Leicester LE1 7RH, UK.

Nucleic Acids Research
|November 21, 2017
PubMed
Summary

RNA G-quadruplexes (G4s) in pre-mRNA influence alternative splicing. Specific G4 ligands modulate Bcl-X pre-mRNA splicing, with one ligand inducing apoptosis by altering splice site selection.

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