Related Experiment Video

Updated: Feb 18, 2026

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

915

Castleman Disease Pathogenesis

David C Fajgenbaum1, Dustin Shilling1

  • 1Division of Translational Medicine and Human Genetics, Hospital of the University of Pennsylvania, 3400 Spruce Street, Silverstein 5, Suite S05094, Philadelphia, PA 19104, USA.

Hematology/Oncology Clinics of North America
|November 22, 2017
PubMed

Insights

Castleman disease (CD) encompasses diverse disorders affecting lymph nodes. This review details the distinct causes, cellular players, and signaling pathways driving each of the four CD subtypes.

Area of Science:

  • Immunology
  • Pathology
  • Oncology

Background:

  • Castleman disease (CD) is a complex group of disorders characterized by specific lymph node abnormalities.
  • CD presents with varied histopathologic features, including germinal center changes, prominent dendritic cells, and lymphoproliferation.

Purpose of the Study:

  • To summarize the current understanding of the etiology and pathogenesis of Castleman disease subtypes.
  • To elucidate the specific causes, cellular mechanisms, signaling pathways, and cytokines involved in each CD subtype.

Main Methods:

  • Literature review and synthesis of existing research on Castleman disease.
  • Comparative analysis of the four recognized subtypes: unicentric CD, HHV-8-associated multicentric CD, POEMS-associated multicentric CD, and idiopathic multicentric CD.

Main Results:

  • Each of the four Castleman disease subtypes has a distinct underlying cause and pathogenesis.
  • Key differences involve viral association (HHV-8), association with POEMS syndrome, or idiopathic origins.
  • Common pathogenic themes include lymphoproliferation and dysregulated cytokine signaling.

Conclusions:

  • Understanding the specific pathogenesis of each CD subtype is crucial for targeted therapeutic strategies.
  • Further research into the molecular mechanisms driving CD subtypes will improve patient outcomes.

Keywords:
Castleman diseaseCytokine stormHHV-8Lymphoproliferative disorderPOEMSTAFRO

More Related Videos

Toxoplasma gondii Cyst Wall Formation in Activated Bone Marrow-derived Macrophages and Bradyzoite Conditions09:56

Toxoplasma gondii Cyst Wall Formation in Activated Bone Marrow-derived Macrophages and Bradyzoite Conditions

Published on: August 12, 2010

16.8K
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.7K

Related Concept Videos

Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.7K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
913
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.4K
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
681
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.4K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.8K