Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Generative Replica Exchange: A Flow-Based Framework for Accelerating Replica-Exchange Simulations.

Journal of chemical theory and computation·2026

Same author

A MYCN-GAL-SREBP1 Lipogenic Axis Drives Proliferation in Silent Corticotroph Adenomas.

Neuro-oncology·2026

Same author

The Effect of Variable Resistance Training on Post-Activation Performance Enhancement: A Systematic Review and Three-Level Meta-analysis.

Sports medicine - open·2026

Same author

Study on the Cytotoxic Effects, Apoptosis Induction, Treatment Resistance, and Inflammation Caused by a Gold(III) Complex Containing 3,4-diaminobenzophenone and 2,3-butanedione Monoxime on the Esophageal Cancer Cell Line KYSE-30.

Current molecular medicine·2026

Same author

Adaptive Cavity-Enabled Crystalline Chirality in Nanocarbon Cages.

Angewandte Chemie (International ed. in English)·2026

Same author

Three-Year Visual Quality Evaluation in Children Using Orthokeratology Lenses: A Retrospective Study With OPD-Scan III Measurements.

Journal of ophthalmology·2026

Same journal

Recent progress in catalytic asymmetric synthesis of triarylmethanes.

Chemical science·2026

Same journal

GFP chromophore photophysics: ultrafast dynamics and hot ground state cooling in the neutral form.

Chemical science·2026

Same journal

Large Stokes shift fluorophores from <i>meta</i>-substituted zwitterions.

Chemical science·2026

Same journal

<i>In situ</i> glycosylation-directed H-aggregation of Type I photosensitizers for synergistic biofilm eradication and promoting diabetic wound healing.

Chemical science·2026

Same journal

Substituent engineering of dynamic covalent bonds enables simultaneous enhancement of performance and recyclability.

Chemical science·2026

Same journal

Visible-light-enabled three-component carboamidation of alkenes with aryl thianthrenium salts.

Chemical science·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 18, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

Cholesterol-directed nanoparticle assemblies based on single amino acid peptide mutations activate cellular uptake

Shang Li¹, Rongfeng Zou^1,2, Yaoquan Tu²

¹Key Laboratory for Advanced Materials & Institute of Fine Chemicals , School of Chemistry and Molecular Engineering , East China University of Science and Technology , Shanghai 200237 , China .

Chemical Science

|November 23, 2017

Summary

This summary is machine-generated.

Scientists developed stable, cell-permeable peptide nanoparticles for cancer therapy. These nanoparticles target cancer cells, induce cell death, and reduce tumor volume in mice, offering a new platform for peptide-based anticancer drugs.

More Related Videos

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Published on: March 8, 2018

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Related Experiment Videos

Last Updated: Feb 18, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Published on: March 8, 2018

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Area of Science:

Biotechnology
Nanomedicine
Drug Delivery

Background:

Peptide drugs face challenges in clinical application due to poor in vivo stability.
Developing stable and effective peptide-based therapeutics remains a significant hurdle.

Purpose of the Study:

To develop a strategy for creating stable peptide-based therapeutic nanoparticles.
To identify cholesterol-modified peptides that enhance peptide stability and cell permeability.
To evaluate the efficacy of these nanoparticles as anticancer agents.

Main Methods:

Screening a library of lysine-modified cholesterol peptides with single-site amino acid mutations.
Characterizing peptide self-assembly into nanoparticles and assessing their stability in serum.
Investigating nanoparticle interaction with cancer cell membranes and evaluating their therapeutic effect in vivo.

Main Results:

Identified cholesterol-modified peptides that stabilize alpha-helix formation and enhance cell permeability.
Developed stable peptide nanoparticles with 68.3% stability after 16h in serum.
Demonstrated nanoparticle-induced cancer cell death via lipid raft-mediated endocytosis.
Observed significant tumor volume reduction in mouse models.

Conclusions:

A novel strategy for developing stable, cell-permeable peptide nanoparticles was established.
The developed peptide nanoparticles show promise as effective anticancer agents.
This platform offers a simplified approach for creating peptide-based anticancer drugs.