Related Experiment Video
Updated: Feb 18, 2026
07:49
Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines
Published on: March 17, 2023
3.2K
Mitochondrial DNA in Lung Cancer
Fangming Liu1, David E Sanin2, Xiangdong Wang3
1Zhongshan Hospital Clinical Science Institute, Fudan University, Shanghai, China.
Advances in Experimental Medicine and Biology
|November 28, 2017
Summary
Mitochondrial DNA (mtDNA) variations, including copy number and mutations, are linked to lung cancer development. Further research is needed to confirm these mtDNA alterations as biomarkers for lung cancer diagnosis and therapy.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Mitochondrial DNA (mtDNA) variations are increasingly recognized in various diseases.
- Lung cancer diagnosis and prognosis can benefit from novel biomarkers.
Purpose of the Study:
- To illustrate alterations of mitochondrial DNA (mtDNA) in lung cancer.
- To explore the potential of mtDNA variations as biomarkers for lung cancer.
- To discuss the mechanisms of mtDNA alterations in lung cancer carcinogenesis.
Main Methods:
- Review of current literature on mtDNA alterations in lung cancer.
- Analysis of mtDNA copy number variations.
- Identification of mtDNA sequence mutations in lung cancer patients.
Main Results:
- Mitochondrial DNA (mtDNA) alterations, including copy number changes and sequence mutations, are observed in lung cancer.
- These alterations may play a role in the carcinogenesis and development of lung cancer.
Conclusions:
- Mitochondrial DNA (mtDNA) variations show potential as biomarkers for monitoring lung cancer.
- Further confirmation of the relationship between mtDNA variations and lung cancer is required for clinical application.
- Understanding mtDNA alterations can aid in developing effective lung cancer diagnosis and therapy strategies.
Related Concept Videos
02:59Animal Mitochondrial Genetics
9.3K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.3K
01:37Mitochondria
20.7K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
20.7K
01:45Mitochondrial Membranes
17.4K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
17.4K
01:29Non-nuclear Inheritance
23.3K
Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm—such as chloroplasts and mitochondria—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.
23.3K