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Organ Bioprinting: Are We There Yet?
Guifang Gao1,2, Ying Huang1, Arndt F Schilling3
1School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, Hubei, 430070, China.
Advanced Healthcare Materials
|December 2, 2017
Summary
3D bioprinting aims to engineer vascularized tissues but remains in its infancy despite advances in 3D printing. Overcoming bottlenecks requires interdisciplinary convergence for viable organ biofabrication.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Tissue Engineering
Background:
- 3D bioprinting emerged 15 years ago as a solution for engineering vascularized tissues, surpassing conventional methods.
- Despite 3D printing advancements, 3D bioprinting faces unique challenges due to the need to incorporate living biological components.
Purpose of the Study:
- To provide a subjective evaluation of the current status of 3D bioprinting in academic and industrial settings.
- To identify and discuss existing bottlenecks hindering the progress of 3D bioprinting technology.
Main Methods:
- Review and subjective evaluation of the current state of 3D bioprinting.
- Discussion of progress and existing challenges in the field.
- Identification of interdisciplinary fields contributing to overcoming bottlenecks.
Main Results:
- True 3D bioprinting for tissue reconstruction is still in its early stages.
- Significant progress has been made, but numerous bottlenecks persist.
- Breakthroughs in fields like material science, cellular biology, and engineering are crucial.
Conclusions:
- A systemic, interdisciplinary approach is necessary to advance 3D bioprinting.
- Convergence of various scientific and engineering disciplines is key to developing viable organ biofabrication.
- 3D bioprinting holds potential for future clinical applications, including transplantation.
