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Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta
Published on: April 3, 2017
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Fetal Membranes-Derived Stem Cells Microenvironment
Phelipe Oliveira Favaron1, Maria Angelica Miglino2
1Surgery Department, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, SP, Brazil.
Advances in Experimental Medicine and Biology
|December 6, 2017
Summary
Fetal membranes offer multipotent stem cells for regenerative medicine. These cells, sourced from the yolk sac and amnion, possess beneficial properties for treating injuries and degenerative diseases in humans and animals.
Area of Science:
- Regenerative Medicine
- Stem Cell Biology
- Tissue Engineering
Background:
- Regenerative medicine integrates tissue engineering and cellular therapy for effective treatments.
- Fetal membranes are a promising source of multipotent stem cells.
- These stem cells exhibit low immunogenicity, anti-inflammatory, and non-tumorigenic properties.
Purpose of the Study:
- To review advances in isolation, phenotyping, and microenvironment characterization of fetal membrane-derived stem cells.
- To explore applications of yolk sac and amniotic membrane stem cells in human and veterinary regenerative medicine.
Main Methods:
- Review of morpho-physiological data on fetal membranes.
- Analysis of stem cell properties and microenvironmental influences.
- Examination of stem cell isolation and characterization techniques.
Main Results:
- Fetal membranes, particularly the yolk sac and amnion, provide stem cells with therapeutic potential.
- The cellular microenvironment significantly influences stem cell behavior, including proliferation and differentiation.
- Diverse embryonic and fetal membrane-derived stem cells offer varied applications.
Conclusions:
- Yolk sac and amniotic membrane-derived stem cells are valuable for regenerative medicine.
- Understanding the microenvironment is crucial for optimizing stem cell therapies.
- These stem cells hold significant promise for treating human and veterinary diseases.
