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Updated: Feb 17, 2026

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Published on: September 19, 2017

Responsive DNA G-quadruplex micelles.

Liliana Cozzoli¹, Lorina Gjonaj, Marc C A Stuart

¹Stratingh Institute for Chemistry, Nijenborgh 4, 9747 AG Groningen, The Netherlands. j.g.roelfes@rug.nl.

Chemical Communications (Cambridge, England)

|December 13, 2017

Summary

This summary is machine-generated.

Novel DNA-lipid conjugates form stable micelles using G-quadruplex structures. These micelles release cargo upon hybridization with complementary DNA, with ATP enabling selective release via a DNA aptamer.

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Area of Science:

Bioconjugate Chemistry
Supramolecular Chemistry
Nanotechnology

Background:

DNA-lipid conjugates offer versatile platforms for nanomaterial design.
G-quadruplex structures are increasingly utilized in self-assembling systems.
Controlled cargo release is critical for drug delivery and diagnostics.

Purpose of the Study:

To present a novel design for DNA-lipid conjugates.
To investigate the role of G-quadruplex formation in micelle assembly and stability.
To demonstrate stimuli-responsive cargo release from these nanostructures.

Main Methods:

Synthesis and characterization of DNA-lipid conjugates.
Formation and analysis of G-quadruplex-based micelles.
Oligonucleotide hybridization for micelle destabilization and cargo release studies.
Utilizing ATP-triggered hairpin DNA aptamers for selective release.

Main Results:

Successfully assembled stable micelles driven by DNA headgroup G-quadruplex formation.
Demonstrated micelle destabilization and cargo release upon hybridization with complementary oligonucleotides.
Achieved ATP-selective cargo release using a hairpin DNA aptamer system.

Conclusions:

DNA-lipid conjugates with G-quadruplex motifs provide a robust platform for self-assembled nanostructures.
The system allows for tunable and stimuli-responsive cargo release.
This design holds potential for applications in targeted delivery and sensing.