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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
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Nutritional metabolomics in critical illness.
1Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts, USA.
Current Opinion in Clinical Nutrition and Metabolic Care
|December 19, 2017
Summary
Metabolomics reveals critical illness disrupts metabolic homeostasis, altering fatty acid, lipid, and tryptophan pathways. Nutritional metabolomics offers insights into nutrient impacts on critical care patients and recovery.
Area of Science:
- Critical care medicine
- Metabolomics
- Nutritional science
Background:
- Metabolic homeostasis is universally disrupted in critically ill patients.
- Macronutrients and micronutrients regulate metabolite production via gene expression.
- Comprehensive metabolite profiling is emerging in critical illness research.
Purpose of the Study:
- To review the application of metabolomics in critical illness.
- To explore nutritional metabolomics in nutrient deficiency and delivery.
- To understand the link between metabolism and critical illness outcomes.
Main Methods:
- Application of metabolomics for comprehensive metabolite profiling.
- Analysis of circulating metabolites in critically ill patients.
- Integration of metabolomics with clinical outcome data.
Main Results:
- Metabolomic studies consistently show alterations in fatty acid, lipid, and tryptophan metabolite pathways.
- These metabolic changes are associated with disease state and patient outcomes.
- Nutritional metabolomics studies examine nutrient deficiency, malnutrition, and delivery.
Conclusions:
- Metabolomics provides a window into metabolic alterations in critical illness.
- Integrating metabolomics with clinical and genomic data enhances understanding of cellular homeostasis.
- Nutritional metabolomics is crucial for understanding recovery from critical illness.
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