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Pattern reversal visual evoked potentials in adults: variability with age.

Raja Sawaya1, Helen Sawaya, Gilbert Youssef

  • 1Department of Neurology, American University Medical Center, Beirut, Lebanon. rs01@aub.edu.lb.

Clinical and Investigative Medicine. Medecine Clinique Et Experimentale
|December 20, 2017
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Summary

Pattern reversal visual evoked potential (PRVEP) testing reveals that visual pathway latencies increase with age. P100 latencies are longer in males, with this difference widening in older age groups.

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Area of Science:

  • Ophthalmology and Neuroscience
  • Electrophysiology
  • Visual Pathway Function

Background:

  • Pattern reversal visual evoked potential (PRVEP) is a key electrophysiological diagnostic tool.
  • Understanding normative PRVEP values across demographics is crucial for clinical interpretation.

Purpose of the Study:

  • To investigate age- and gender-related changes in PRVEP latencies and amplitudes.
  • Establish normative data for PRVEP parameters in a healthy adult population.

Main Methods:

  • Recruited 81 healthy participants (20-92 years).
  • Monocular stimulation with a 30° checkerboard pattern at 2 Hz.
  • Measured N75, P100, N145 latencies and N75-P100 amplitude, analyzing by decade.

Main Results:

  • All measured latencies showed a linear trend with age, generally increasing.
  • PRVEP amplitude (N75-P100) demonstrated a decrease with advancing age.
  • P100 latencies were consistently longer in males compared to females, with the disparity growing with age.

Conclusions:

  • Age significantly impacts visual pathway conduction times, as evidenced by PRVEP latency changes.
  • Gender is also a factor, with males exhibiting longer P100 latencies, particularly in older individuals.
  • These findings contribute to age- and gender-specific normative data for PRVEP analysis.