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Short-term change in higher-order aberrations after mitomycin-C-augmented trabeculectomy.
Seong Ho Jo1,2, Je Hyun Seo3,4
1Department of Ophthalmology, Pusan National University Yangsan Hospital, Yangsan, Korea.
International Ophthalmology
|December 24, 2017
Summary
Glaucoma surgery (trabeculectomy) with mitomycin-C can temporarily increase higher-order aberrations (HOA) in phakic patients. These visual disturbances are more pronounced in phakic individuals compared to pseudophakic ones.
Area of Science:
- Ophthalmology
- Glaucoma Surgery
- Ocular Aberrations
Background:
- Trabeculectomy with mitomycin-C (MMC) is a common glaucoma surgery.
- Understanding post-operative visual quality is crucial for patient outcomes.
Purpose of the Study:
- To investigate changes in ocular higher-order aberrations (HOA) after trabeculectomy with MMC.
- To compare HOA changes between phakic and pseudophakic patients.
Main Methods:
- Retrospective review of 63 eyes undergoing MMC-augmented trabeculectomy.
- Measurement of intraocular pressure, refractive errors, anterior chamber depth, and HOA pre- and post-operatively.
- Comparison of HOA using paired t-tests and regression analysis, stratified by preoperative lens status.
Main Results:
- Significant increase in total HOA and coma-like aberrations at 1 week post-surgery in phakic eyes.
- Corneal and internal optics HOA also increased in phakic eyes at 1-2 weeks.
- No significant HOA changes were observed in pseudophakic eyes at any time point.
Conclusions:
- Trabeculectomy with MMC can induce temporary HOA, particularly in phakic patients.
- Phakic patients may experience more profound HOA-related visual complaints post-surgery.
- HOA changes did not correlate with age, ACD, or IOP changes.
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