Review on microfluidic paper-based analytical devices towards commercialisation.

Area of Science:

• Analytical Chemistry
• Materials Science
• Biotechnology

Background:

• Paper-based analytical devices (PADs) are a promising platform for low-cost, portable fluid analysis.
• Their fabrication and operation are simple, requiring minimal equipment.
• Widespread adoption is hindered by challenges in mass production and fluid control.

Purpose of the Study:

• To provide a comprehensive overview of PAD fabrication techniques.
• To identify limitations in current fabrication methods and discuss emerging solutions.
• To highlight novel technologies for effective fluid handling and control in PADs.

Main Methods:

• Literature review of fabrication techniques for paper-based analytical devices.
• Analysis of existing methods for fluid handling and control.
• Identification and discussion of recent advancements in PAD technology.

Main Results:

• Various fabrication techniques for PADs exist, each with specific advantages and drawbacks.
• Current mass production methods face limitations impacting commercialization.
• Novel approaches for precise fluid control are emerging in recent literature.

Conclusions:

• Effective fluid control is critical for the advancement and market viability of PADs.
• Overcoming fabrication and fluid control challenges will accelerate the transition of PADs from lab to consumer use.
• Continued innovation in PAD technology is essential for realizing their full potential.