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Updated: Feb 15, 2026

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
Published on: September 19, 2018
Relationship between Hedgehog Signaling Pathway and Drug Resistance of Poorly Differentiated Gliomas
S A Cherepanov1,2, N F Grinenko3, O M Antonova3
1N. I. Pirogov National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia. cherep-rsmu@yandex.ru.
Abstract:
The effects of Hedgehog signaling inhibitor (cyclopamine) and activator (Shh) on drug resistance of U251-MG human glioma cells and human astrocyte culture to cisplatin, temozolomide, and doxorubicin were studied. Cyclopamine and Shh modified the drug resistance of U251-MG cells but not of human astrocytes. Experiments with cyclopamine, Shh, and chemical drugs can contribute to detection of the mechanisms of signaling effects on the drug resistance processes, while the experimental data can serve as one of the criteria for choosing individual chemotherapy for patients.
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