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Pediatric psoriasis: Evolving perspectives
Lawrence F Eichenfield1,2, Amy S Paller3,4, Wynnis L Tom1,2
1Department of Dermatology, University of California, San Diego School of Medicine and Rady Children's Hospital, San Diego, CA, USA.
Insights
Childhood-onset psoriasis, a common inflammatory skin disease, significantly impacts children and families. This review offers practical guidance for managing pediatric psoriasis due to evolving data and treatments.
Area of Science:
- Dermatology
- Pediatrics
- Immunology
Background:
- Childhood-onset psoriasis is a prevalent skin condition with substantial medical, social, and psychological burdens.
- Limited data and management guidelines exist for pediatric psoriasis, necessitating expert consensus.
Purpose of the Study:
- To provide an updated critical overview of pediatric psoriasis.
- To offer practical guidance for managing children with psoriasis.
Main Methods:
- Expert panel of pediatric dermatologists convened.
- Comprehensive English-language literature review conducted.
- Consensus meeting and manuscript preparation followed.
Main Results:
- Evolving perspectives cover epidemiology, natural history, comorbidities, quality of life, and clinical features.
- Differential diagnosis, pathogenesis, and treatment options (topical, photo, systemic) are discussed.
- Current management relies on expert consensus, with accumulating pediatric data.
Conclusions:
- Pediatric psoriasis is a significant immune-mediated inflammatory disease impacting children and caregivers.
- Therapeutic options are rapidly evolving, supported by increasing pediatric data.
- Expert consensus guides current care for childhood-onset psoriasis.
Background/Objectives:
Childhood-onset psoriasis is a common skin disorder that has recently received increasing attention, particularly because of its significant medical, social, financial, and psychological burdens and its associated comorbidities. With limited data available and lack of standardized management guidelines for pediatric psoriasis, an expert panel desired to provide an updated critical overview and practical guidance for management of the affected population.
Methods:
A panel of pediatric dermatologists with extensive experience in pediatric psoriasis defined and prioritized a core set of topics, performed an English-language literature review, prepared critical evaluations and presentations of topic areas, and carried out a consensus meeting and follow-up consensus manuscript.
Results:
The summation of evolving perspectives in pediatric psoriasis includes epidemiology and natural history of the disease, precipitating factors and comorbidities, quality of life and burden of disease, clinical features and disease presentation, differential diagnosis, pathogenesis and treatment, including topical, photo, and systemic therapies.
Conclusion:
Pediatric psoriasis is an important immune-mediated inflammatory skin disease with potential for significant impact on affected individuals and their caregivers. Current state-of-the-art care is based primarily on experience and expert consensus, but pediatric data are accumulating and therapeutic options are rapidly evolving.
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