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The full-length sequence of the HLA-C allele, HLA-C*15:13:01:01

Z Li1, H-Y Zou1, D Zhou1

  • 1Shenzhen Blood Center, Immunogenetic Laboratory, Shenzhen Institute of Transfusion Medicine, Shenzhen, China.

HLA
|January 10, 2018
PubMed

Insights

Researchers confirmed the complete genetic sequence of the HLA-C*15:13:01:01 allele. This finding was achieved through cloning and sequencing in a Chinese donor, contributing to human leukocyte antigen (HLA) knowledge.

Area of Science:

  • Immunogenetics
  • Molecular Biology

Background:

  • Human Leukocyte Antigen (HLA) genes are critical for immune response.
  • Accurate HLA typing is essential for transplantation and disease association studies.

Purpose of the Study:

  • To determine the full-length nucleotide sequence of the HLA-C*15:13:01:01 allele.
  • To provide a precise genetic reference for this specific HLA-C variant.

Main Methods:

  • Cloning of the HLA-C*15:13:01:01 gene.
  • DNA sequencing using established molecular biology techniques.

Main Results:

  • The complete coding sequence of HLA-C*15:13:01:01 was successfully determined.
  • Confirmation of the allele's sequence in a Chinese donor population.

Conclusions:

  • The confirmed sequence provides a valuable resource for immunogenetic research.
  • This precise data aids in understanding HLA diversity and its clinical implications.

Keywords:
cloning and sequencingfull-length sequencehuman leukocyte antigen

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