EXPRESSION OF CYCLIN E IN BASAL-LIKE BREAST CARCINOMA
A Mariamidze1, L Gogiashvili1, O Khardzeishvili1
1Davit Tvildiani Medical University; I. Javakhishvili Tbilisi State University; Tbilisi State Medical University, Georgia.
Georgian Medical News
|January 13, 2018
Summary
Basal-like breast carcinoma shows varied responses to Cyclin E, CK5/17, and ER/PR markers. Cyclin E reactivity in basal-like tumors correlates with advanced clinical stages (III-IV) and poorer prognosis.
Area of Science:
- Oncology
- Pathology
- Biomarkers
Background:
- Basal-like breast carcinoma is an aggressive subtype.
- Immunohistochemistry is crucial for breast cancer subtyping.
- Understanding biomarker expression is key to prognosis.
Purpose of the Study:
- To investigate the immunoreactivity of Cyclin E, CK5/17, and ER/PR in basal-like breast carcinoma.
- To correlate these biomarker expressions with clinical stages and patient prognosis.
Main Methods:
- Analysis of 362 biopsy materials from patients at Tbilisi National Cancer Center.
- Immunohistochemical staining for Cyclin E, CK5/17, and Estrogen Receptor/Progesterone Receptor (ER/PR).
- Correlation of biomarker expression with clinical stage and prognosis.
Main Results:
- Basal-like breast carcinoma exhibits distinct immunoreactivity patterns for Cyclin E, CK5/17, and ER/PR.
- Cyclin E immunoreactivity significantly correlates with clinical stage, particularly stages III-IV.
- Increased Cyclin E expression is associated with a poor prognosis in basal-like breast cancer.
Conclusions:
- Immunohistochemical markers like Cyclin E can help characterize basal-like breast carcinoma.
- Cyclin E serves as a potential prognostic indicator for advanced-stage basal-like breast cancer.
- These findings aid in understanding the heterogeneity and clinical behavior of basal-like tumors.
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