DISTRIBUTION AND DEMOGRAPHIC CHARACTERISTICS OF DUCTAL INVASIVE BREAST CARCINOMA SUBTYPES IN GEORGIAN POPULATION

Area of Science:

• Oncology
• Pathology
• Epidemiology

Background:

• Ductal invasive breast carcinoma (DIBC) exhibits diverse subtypes with potentially varying age-specific prevalence.
• Understanding these age-related patterns is crucial for optimizing breast cancer screening and treatment strategies.

Purpose of the Study:

• To analyze the prevalence of specific ductal invasive breast carcinoma subtypes across different age groups.
• To identify age-related trends and specificities of DIBC phenotypes.

Main Methods:

• Retrospective analysis of DIBC subtypes based on age group categories.
• Statistical evaluation of subtype prevalence across age strata (I-VI, 30-79 years).

Main Results:

• Luminal A subtype is the dominant DIBC subtype across all age groups, with peaks in groups III and IV.
• Her2(+)/ER subtype is the second most prevalent, showing a general decrease with age until group V, then an increase.
• Basal-like and Triple-negative subtypes increase with age, absent in younger groups (I and VI), with notable prevalence in older groups.

Conclusions:

• Age-specific prevalence of DIBC subtypes varies significantly, impacting diagnostic and therapeutic approaches.
• Tailoring breast cancer screening programs based on age-related subtype distributions is recommended.
• Further research is needed to explore correlations between family history and DIBC subtypes.